The risk of cytomegalovirus transmission by penetrating keratoplasty

Am J Ophthalmol. 1988 Apr 15;105(4):357-60. doi: 10.1016/0002-9394(88)90297-8.

Abstract

To investigate the risk of cytomegalovirus transmission by corneal transplantation, we quantitated anticytomegalovirus IgG levels of donor, preoperative, and postoperative serum samples. Of 118 patients, 79 (67%) were seropositive preoperatively. Twenty-five patients who were seronegative preoperatively received a graft from a positive donor and two (8%) seroconverted. Eleven patients who were seronegative preoperatively received a graft from a negative donor and one (9%) seroconverted. None of the patients who seroconverted had a febrile illness and all three grafts were clear.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antibodies, Viral / analysis
  • Cornea / microbiology
  • Corneal Transplantation*
  • Cytomegalovirus / immunology
  • Cytomegalovirus Infections / transmission*
  • Humans
  • Immune Tolerance
  • Middle Aged
  • Risk Factors
  • Serologic Tests
  • Tissue Donors

Substances

  • Antibodies, Viral