Prevention of DNA damage and anticarcinogenic activity of Activia® in a preclinical model

Genet Mol Res. 2017 Mar 22;16(1). doi: 10.4238/gmr16019492.

Abstract

Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa.

MeSH terms

  • 1,2-Dimethylhydrazine
  • Aberrant Crypt Foci / chemically induced
  • Aberrant Crypt Foci / genetics
  • Aberrant Crypt Foci / pathology
  • Aberrant Crypt Foci / prevention & control*
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Colorectal Neoplasms / chemically induced
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / pathology
  • Colorectal Neoplasms / prevention & control*
  • DNA Damage*
  • Dietary Supplements
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / pathology
  • Male
  • Mice
  • Probiotics / pharmacology*
  • Yogurt / microbiology*

Substances

  • Anticarcinogenic Agents
  • 1,2-Dimethylhydrazine