Experimental Evolution to Study Virus Emergence

Cell. 2017 Mar 23;169(1):1-3. doi: 10.1016/j.cell.2017.03.018.


Understanding how viruses adapt to new environments and acquire new phenotypes is critical for developing comprehensive responses to outbreaks. By studying the emergence of vaccine-derived poliovirus outbreaks, Stern et al. describe how a combination of sequence analysis and experimental evolution can be used to reveal adaptive pathways.

MeSH terms

  • Biological Evolution
  • Disease Outbreaks
  • Poliomyelitis / epidemiology*
  • Poliovirus / genetics
  • Poliovirus Vaccine, Oral*


  • Poliovirus Vaccine, Oral