Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).
Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.
Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.
Limitations: Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.
Conclusion: The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.
Keywords: Polypodium leucotomos extract; colorimetry; cyclobutane pyrimidine dimers; excimer laser; minimal erythema dose; sunburn cells; ultraviolet.
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