Mitochondrial transplantation: From animal models to clinical use in humans

Mitochondrion. 2017 May;34:127-134. doi: 10.1016/j.mito.2017.03.004. Epub 2017 Mar 22.

Abstract

Mitochondrial transplantation is a novel therapeutic intervention to treat ischemia/reperfusion related disorders. The method for mitochondrial transplantation is simple and rapid and can be delivered to the end organ either by direct injection or vascular infusion. In this review, we provide mechanistic and histological studies in large animal models and present data to show clinical efficacy in human patients.

Keywords: Cardiac; Ischemia; Mitochondria; Reperfusion.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Products / therapeutic use*
  • Disease Models, Animal
  • Mitochondria / physiology*
  • Reperfusion Injury / therapy*
  • Transplantation / methods*
  • Treatment Outcome

Substances

  • Biological Products