Anti-skin-aging effect of epigallocatechin gallate by regulating epidermal growth factor receptor pathway on aging mouse model induced by d-Galactose

Mech Ageing Dev. 2017 Jun:164:1-7. doi: 10.1016/j.mad.2017.03.007. Epub 2017 Mar 24.


Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty-five male mice were divided into 5 groups and treated with different dose of EGCG, Vitamin C (VitC) to mice as a positive control. All groups except vehicle were established aging model induced by d-galactose (200mg/kg/day) that was subcutaneously injected to mice for 8 weeks. Two weeks after injection of d-galactose, EGCG and Vit C groups were simultaneously administered once a day by subcutaneously inject after 5h for injecting d-galactose. The results show that EGCG can be absorbed by the skin. Overall, the conditions of the skin of EGCG-treatment groups were improved, the whole structure of skin were better than control groups, and the levels of oxidative stress and the expression of relate with EGFR proteins were significantly higher than control group after EGCG treatment. All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.

Keywords: Anti-skin-aging; EGCG; EGFR pathway; Oxidative stress; d-galactose.

MeSH terms

  • Animals
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • ErbB Receptors / metabolism*
  • Galactose / toxicity*
  • Male
  • Mice
  • Models, Biological
  • Signal Transduction / drug effects*
  • Skin Aging / drug effects*


  • Catechin
  • epigallocatechin gallate
  • EGFR protein, mouse
  • ErbB Receptors
  • Galactose