Peripheral and central fatigue after high intensity resistance circuit training

Muscle Nerve. 2017 Jul;56(1):152-159. doi: 10.1002/mus.25460. Epub 2017 Mar 27.


Introduction: The aim of this study was to investigate the effects of high intensity resistance circuit (HIRC) and traditional strength training (TST) on neuromuscular fatigue and metabolic responses.

Methods: Twelve trained young subjects performed HIRC and TST in a counterbalanced order with 1 week rest in-between. The amount of workload and the inter-set time for each local muscle group were matched (180 s), however, the time between successive exercises differed. The twitch interpolation technique was used to test neuromuscular function of the knee extensor muscles. Blood lactate concentration was used to evaluate metabolic responses.

Results: Maximum voluntary contraction and resting potentiated twitch amplitude (Qtw ) were significantly reduced after HIRC, but there were not changes after TST, while reductions in voluntary activation were similar. Lactate concentration increased significantly more after HIRC.

Conclusions: The higher lactate concentration after HIRC probably impaired excitation-contraction coupling, indicating larger peripheral fatigue than after TST. Muscle Nerve 56: 152-159, 2017.

Keywords: fatigue; metabolic response; neuromuscular function; perception of effort; resistance training; twitch interpolation technique.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cerebellar Ataxia / complications
  • Cerebellar Ataxia / diagnostic imaging
  • Cerebellar Ataxia / rehabilitation*
  • Circuit-Based Exercise / methods*
  • Female
  • Humans
  • Lactic Acid / metabolism
  • Male
  • Median Nerve / diagnostic imaging
  • Muscle Fatigue / physiology*
  • Ulnar Nerve / diagnostic imaging
  • Vestibular Diseases / complications
  • Vestibular Diseases / diagnostic imaging
  • Vestibular Diseases / rehabilitation


  • Lactic Acid