[Primary prostatic sarcoma - a rare malignancy]

Urologe A. 2017 Jul;56(7):857-860. doi: 10.1007/s00120-017-0370-z.
[Article in German]


Primary prostatic sarcomas are rare, reportedly comprising less than 1% of all prostate malignancies. Most patients present with lower urinary tract symptoms due to bladder outlet obstruction. Prostate-specific antigen (PSA) is typically normal. Histological confirmation and staging by a computed tomography (CT) or magnetic resonance imaging (MRI) scan of the pelvis and abdomen are essential for diagnosis and treatment planning. The differential diagnosis includes sarcomatoid prostate cancer or benign spindle cell tumors. Primary prostatic sarcomas are often aggressive and require multimodal treatment with surgery and (neo)adjuvant radiation and/or chemotherapy. The risk of local recurrence is high and the long-term prognosis is poor.

Keywords: Histopathology; Leiomyosarcoma; Rhabdomyosarcoma; Stromal sarcoma; Tumor, mesenchymal.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Chemoradiotherapy, Adjuvant
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Endosonography
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / etiology
  • Neoplasm Recurrence, Local / mortality
  • Prognosis
  • Prostate / pathology
  • Prostatectomy
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / mortality
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy
  • Sarcoma / diagnosis*
  • Sarcoma / mortality
  • Sarcoma / pathology
  • Sarcoma / therapy
  • Survival Rate
  • Tomography, X-Ray Computed
  • Urinary Bladder Neck Obstruction / diagnosis
  • Urinary Bladder Neck Obstruction / etiology
  • Urinary Bladder Neck Obstruction / mortality
  • Urinary Bladder Neck Obstruction / pathology