Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group

Clin Infect Dis. 2017 Mar 15;64(suppl_1):S41-S47. doi: 10.1093/cid/ciw831.


Diagnostics are a cornerstone of the practice of infectious diseases. However, various limitations frequently lead to unmet clinical needs. In most other domains, diagnostics focus on narrowly defined questions, provide readily interpretable answers, and use true gold standards for development. In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens of clinical syndromes, emerging pathogens, rapid evolution of existing pathogens and their associated resistance mechanisms, and the absence of gold standards in many situations. In spite of these challenges, the importance and value of diagnostics cannot be underestimated. Therefore, the Antibacterial Resistance Leadership Group has identified diagnostics as 1 of 4 major areas of emphasis. Herein, we provide an overview of that development, highlighting several examples where innovation in study design, content, and execution is advancing the field of infectious diseases diagnostics.

Keywords: antibacterial resistance; devices.; diagnostics.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / diagnosis*
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / microbiology
  • Biological Specimen Banks
  • Clinical Studies as Topic
  • Drug Resistance, Bacterial*
  • Host-Pathogen Interactions
  • Humans
  • Laboratories
  • Leadership
  • Molecular Diagnostic Techniques
  • Professional Staff Committees / organization & administration
  • Research Design
  • Sepsis / diagnosis
  • Sepsis / microbiology


  • Anti-Bacterial Agents