Use of liposomes as carriers for radiation synovectomy

Int J Rad Appl Instrum B. 1988;15(2):151-6. doi: 10.1016/0883-2897(88)90081-5.

Abstract

Using [99mTc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99mTc-containing liposomes into the knee joints of rabbits, retention of 99mTc in the knee was more than 200 times greater than following injection of nonencapsulated [99mTc]pertechnetate. The knee clearance biologic half time of 99mTc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111In(oxine), a knee clearance biologic half time of greater than 1200 h was observed.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Indium Radioisotopes
  • Liposomes / administration & dosage*
  • Organometallic Compounds / therapeutic use
  • Oxyquinoline / analogs & derivatives
  • Oxyquinoline / therapeutic use
  • Permeability
  • Phosphatidylcholines
  • Rabbits
  • Sodium Pertechnetate Tc 99m / pharmacokinetics
  • Sodium Pertechnetate Tc 99m / therapeutic use*
  • Sphingomyelins
  • Synovial Membrane / radiation effects*
  • Tissue Distribution

Substances

  • Indium Radioisotopes
  • Liposomes
  • Organometallic Compounds
  • Phosphatidylcholines
  • Sphingomyelins
  • indium oxine
  • Oxyquinoline
  • Sodium Pertechnetate Tc 99m
  • 1,2-distearoyllecithin