Sensory peripheral neuropathy of vitamin B12 deficiency: a primary demyelinating disease?

J Neurol. 1988 Jan;235(3):163-4. doi: 10.1007/BF00314308.


In five patients with peripheral neuropathy due to vitamin B12 deficiency, electrodiagnostic studies demonstrated severe reduction in sensory nerve conduction velocities compatible with a demyelinating disorder affecting sensory nerve fibres. It is suggested that in some patients lack of vitamin B12 may cause primary sensory demyelinating neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Demyelinating Diseases / etiology*
  • Demyelinating Diseases / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Conduction
  • Peripheral Nervous System Diseases / etiology*
  • Peripheral Nervous System Diseases / physiopathology
  • Vitamin B 12 Deficiency / complications*
  • Vitamin B 12 Deficiency / physiopathology