Role of Chirality in Drugs: An Overview

Infect Disord Drug Targets. 2018;18(2):88-95. doi: 10.2174/1871526517666170329123845.

Abstract

Stereochemistry has occupied a great role in the manufacture and development of pharmaceuticals. Chiral properties play an important role in the determination of pharmacological actions of the drug. In recent years, there is a considerable interest in chiral separation to isolate and examine both enantiomers. This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for enantiomeric pairs.

Keywords: Chirality; chiral drug; chiral separation; enantiomer; pharmacology; stereoisomer..

Publication types

  • Review

MeSH terms

  • Chromatography
  • Crystallization
  • Drug Design
  • Electrophoresis, Capillary
  • Humans
  • Pharmaceutical Preparations* / analysis
  • Pharmaceutical Preparations* / chemistry
  • Pharmaceutical Preparations* / isolation & purification
  • Pharmacokinetics
  • Stereoisomerism

Substances

  • Pharmaceutical Preparations