Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general community. Despite major advances in treatment strategies, as many as 90% of patients with gout are poorly controlled or improperly managed and their hyperuricemia and recurrent flares continue. The introduction of novel urate-lowering therapies, new imaging modalities, and a deeper understanding of the pathogenesis of gout raise the possibility of better gout care and improved patient outcomes. Here, we spotlight recent advances in the diagnosis and management of gout and discuss novel therapeutics in gout treatment.
Keywords: gout; gout treatment; urate-lowering therapy.
Conflict of interest statement
Competing interests: Talia F. Igel declares that she has no competing interests. Svetlana Krasnokutsky has served as a consultant for Crealta, Horizon and Ironwood. Michael H. Pillinger serves or has served as a consultant for AstraZeneca, Crealta, Horizon, Ironwood and Sobi and has been an investigative site for a sponsored trial by Takeda.No competing interests were disclosed.No competing interests were disclosed.
New and Pipeline Drugs for GoutRT Keenan et al. Curr Rheumatol Rep 18 (6), 32. PMID 27097819. - ReviewGout is the most common inflammatory arthropathy in the western world. Affecting millions and accounting for lost wages, increased health care costs, and significant disa …
Treatment Approaches and Adherence to Urate-Lowering Therapy for Patients With GoutT Aung et al. Patient Prefer Adherence 11, 795-800. PMID 28458524. - ReviewGout is the most common inflammatory arthritis characterized by painful disabling acute attacks. It is caused by hyperuricemia and deposition of urate crystals in and aro …
What Do I Need to Know About Gout?MA Becker et al. J Fam Pract 59 (6 Suppl), S1-8. PMID 20544070. - ReviewMany patients with gout present with an acute attack (flare) of gouty arthritis. In its early stages, gout is a chronic, often silent disorder punctuated by acute, extrem …
Overview of Serum Uric Acid Treatment Targets in Gout: Why Less Than 6 mg/dL?G Ruoff et al. Postgrad Med 128 (7), 706-15. PMID 27558643. - ReviewGout is a progressive, painful, debilitating form of inflammatory arthritis. It is caused by factors that elevate the concentration of serum uric acid (sUA), leading to h …
CaseBook Challenges: Managing Gout, Hyperuricemia and Comorbidities -- Dialogue With the ExpertsGL Bakris et al. Am J Med 127 (1), S1. PMID 24268074.The prevalence of gout and hyperuricemia are on the rise in the United States corresponding with an increase in risk factors for these conditions, such as obesity, metabo …
Cited by 3 PubMed Central articles
Patients Prescribed Anakinra for Acute Gout Have Baseline Increased Burden of Hyperuricemia, Tophi, and Comorbidities, and Ultimate All-Cause MortalityE Sharma et al. Clin Med Insights Arthritis Musculoskelet Disord 12, 1179544119890853. PMID 31839715.At baseline rheumatology gout encounter, higher urate, palpable tophi, statin prescription, and East Asian descent were associated with later anakinra use for flares. Mor …
Toxicological Evaluation of Saposhnikoviae Radix Water Extract and Its Antihyperuricemic PotentialCW Kim et al. Toxicol Res 35 (4), 371-387. PMID 31636848.Although the dried root of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a popular medicinal plant in East Asia, there has been no systemic toxicol …
Impaired Arterial Responsiveness in Untreated Gout Patients Compared With Healthy Non-Gout Controls: Association With Serum Urate and C-reactive ProteinS Krasnokutsky et al. Clin Rheumatol 37 (7), 1903-1911. PMID 29450849.To determine whether arterial responsiveness is impaired among patients with gout, and whether arterial responsiveness inversely correlates with serum urate and inflammat …