A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation

Jelena Ostojić; Jean-Paul Rago; Geneviève Dujardin

doi:10.15698/mic2014.01.123

A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation

Microb Cell. 2014 Jan 6;1(1):43-44. doi: 10.15698/mic2014.01.123.

Authors

Jelena Ostojić¹, Jean-Paul Rago², Geneviève Dujardin¹

Affiliations

¹ Centre de Génétique Moléculaire, Université Paris-Sud, avenue de la Terrasse, 91190 Gif sur Yvette, France.
² University Bordeaux, Institut de Biochimie et Génétique Cellulaires, UMR 5095, 33000 Bordeaux, France. ; CNRS, Institut de Biochimie et Génétique Cellulaires, UMR 5095, 33000 Bordeaux, France.

Abstract

Mitochondria are essential organelles that are central to a multitude of cellular processes, including oxidative phosphorylation (OXPHOS), which produces most of the ATP in animal cells. Thus it is important to understand not only the mechanisms and biogenesis of this energy production machinery but also how it is regulated in both physiological and pathological contexts. A recent study by Ostojić et al. [Cell Metabolism (2013) 18, 567-577] has uncovered a regulatory loop by which the biogenesis of a major enzyme of the OXPHOS pathway, the respiratory complex III, is coupled to the energy producing activity of the mitochondria.

Keywords: AAA protein Bcs1; ATP synthase; OXPHOS complex III; mitochondrial-disease model; yeast.

Publication types

Comment

Grants and funding

We thank Drs C. Panozzo and CJ Herbert for critical reading of the manuscript. J.O. was supported by a fellowship from the French Ministery of Research and Technologies.