The lack of effect of chronic administration of imipramine and electroconvulsive shock on opioid mu, delta and kappa receptors in the spinal cord

Pol J Pharmacol Pharm. Jul-Aug 1987;39(4):387-91.

Abstract

Chronic administration of imipramine (10 mg/kg/day for 21 days) and ECS (8 daily treatments) did not change parameters of specific spinal binding sites for [3H]naloxone, [3H]DADLE and [3H]bremazocine. The results indicate that chronic antidepressant treatment does not affect spinal opioid receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electroshock*
  • Imipramine / pharmacology*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Opioid / metabolism*
  • Receptors, Opioid / physiology
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • Spinal Cord / metabolism*

Substances

  • Receptors, Opioid
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • Imipramine