Bilateral Lung Transplantation for Bleomycin-Associated Lung Injury

Vivek Narayan; Charuhas Deshpande; Christian A Bermudez; Jaclyn M Golato; James C Lee; Joshua Diamond; David J Vaughn

doi:10.1634/theoncologist.2016-0437

Bilateral Lung Transplantation for Bleomycin-Associated Lung Injury

Oncologist. 2017 May;22(5):620-622. doi: 10.1634/theoncologist.2016-0437. Epub 2017 Mar 30.

Authors

Vivek Narayan¹, Charuhas Deshpande², Christian A Bermudez³, Jaclyn M Golato⁴, James C Lee⁵, Joshua Diamond⁵, David J Vaughn⁶

Affiliations

¹ Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
² Division of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
³ Cardiac Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
⁴ Penn Transplant Center, Lung Program, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁵ Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
⁶ Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA david.vaughn@uphs.upenn.edu.

Abstract

This report details the successful use of bilateral lung transplantation for the management of severe postoperative bleomycin-associated lung injury. This case highlights that the extremely favorable prognosis of advanced testicular germ cell tumors after systemic chemotherapy (>90% cure rate) should not preclude lung transplant consideration in all cases, despite current guidance that considers an advanced malignancy to be a contraindication for lung transplant listing. The Oncologist 2017;22:620-622.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Bleomycin / administration & dosage
Bleomycin / adverse effects*
Cisplatin / administration & dosage
Cisplatin / adverse effects
Etoposide / administration & dosage
Etoposide / adverse effects
Humans
Lung Injury / chemically induced
Lung Injury / diagnostic imaging
Lung Injury / pathology
Lung Injury / therapy*
Lung Transplantation*
Male
Neoplasms, Germ Cell and Embryonal / complications*
Neoplasms, Germ Cell and Embryonal / drug therapy
Neoplasms, Germ Cell and Embryonal / pathology
Testicular Neoplasms / complications*
Testicular Neoplasms / drug therapy
Testicular Neoplasms / pathology

Substances

Bleomycin
Etoposide
Cisplatin

Supplementary concepts

Testicular Germ Cell Tumor