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. 2017 Mar;162(5):654-657.
doi: 10.1007/s10517-017-3680-7. Epub 2017 Mar 31.

Changes in the Structure of the Thymus Under Conditions of Various Treatments for Experimental Mammary Tumor

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Changes in the Structure of the Thymus Under Conditions of Various Treatments for Experimental Mammary Tumor

O V Kazakov et al. Bull Exp Biol Med. .

Abstract

Morphological changes in the thymus of female Wistar rats with experimental mammary gland carcinomas were studied. After adjuvant therapy, the area of the cortical matter and density of parenchymal cells in the thymus decreased, while areas of the medulla, connective tissue, and content of immunoblasts and macrophages increased. In the thymuses of rats receiving exogenous DNA, morphological signs of activation of the lymphoid and epithelial components were found: areas of the cortex and medulla, glandular and connective tissue corresponded to the values in intact animals, the counts of lymphocytes in the central part of the cortical matter and of macrophages in all zones of the thymus increased, and lymphocyte migration from the thymus increased (in comparison with the chemotherapy group).

Keywords: double-stranded DNA; lymphocytes; mammary tumor; thymus.

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