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. 2017 Mar 31;19(4):263-265.
doi: 10.1038/ncb3504.

PARL Paves the Way to Apoptosis


PARL Paves the Way to Apoptosis

Naotada Ishihara et al. Nat Cell Biol. .


Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.

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