Talin gets SHANKed in the fight for integrin activation

Nat Cell Biol. 2017 Mar 31;19(4):265-267. doi: 10.1038/ncb3501.


Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.

Publication types

  • Comment

MeSH terms

  • Cell Adhesion*
  • Extracellular Matrix
  • Humans
  • Integrins / genetics
  • Talin / genetics*


  • Integrins
  • Talin