Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Appl Physiol Nutr Metab. 2017 Aug;42(8):841-849. doi: 10.1139/apnm-2016-0644. Epub 2017 Mar 31.


Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.

Keywords: diet-induced obesity; glucose tolerance; inflammation; insulin sensitivity; obésité d’origine alimentaire; oxidative stress; rat; sensibilité insulinique; stress oxydatif; tolérance au glucose.

MeSH terms

  • Adiponectin / blood
  • Animals
  • Anostraca
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • Diet, High-Fat
  • Dietary Fats / administration & dosage*
  • Fatty Acids, Nonesterified / blood
  • Glucose Intolerance / diet therapy
  • Glycated Hemoglobin / metabolism
  • Insulin / blood
  • Insulin Resistance*
  • Leptin / blood
  • Male
  • Obesity / diet therapy*
  • Oils / administration & dosage*
  • Oxidative Stress / drug effects
  • Rats
  • Shellfish*
  • Vitamin A / administration & dosage
  • Vitamin E / administration & dosage
  • Xanthophylls / administration & dosage


  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Dietary Fats
  • Fatty Acids, Nonesterified
  • Glycated Hemoglobin A
  • Insulin
  • Leptin
  • Oils
  • Xanthophylls
  • Vitamin A
  • Vitamin E
  • astaxanthine