Heterotopic Ossification Following Upper Extremity Injury

Shailesh Agarwal; Shawn Loder; Benjamin Levi

doi:10.1016/j.hcl.2016.12.013

Heterotopic Ossification Following Upper Extremity Injury

Hand Clin. 2017 May;33(2):363-373. doi: 10.1016/j.hcl.2016.12.013.

Authors

Shailesh Agarwal¹, Shawn Loder¹, Benjamin Levi²

Affiliations

¹ Section of Plastic Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
² Section of Plastic Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: blevi@umich.edu.

Abstract

Heterotopic ossification (HO) presents a substantial barrier to rehabilitation for patients with severe burns or trauma. Although surgical excision is a mainstay of management for this condition, this is unable to address the chronic sequelae of HO, including chronic pain, joint contractures, nerve dysfunction, and open wounds. Current therapeutic modalities are aimed at excision and the prevention of recurrence using nonsteroidal antiinflammatory drugs (NSAIDs) or radiation therapy. Research is now focused on identifying alternative strategies to prevent the initial occurrence of HO through NSAIDs and novel inhibitors of the bone morphogenetic protein signaling pathway.

Keywords: Burn injury; Elbow; Heterotopic ossification; Upper extremity.

Publication types

Review

MeSH terms

Arm Injuries / complications*
Burns / complications*
Contracture / complications
Elbow Joint
Humans
Joint Dislocations / complications
Ossification, Heterotopic / etiology*
Range of Motion, Articular

Abstract

Publication types

MeSH terms

Grant support