Abstract
The amounts of mRNA for glutathione S transferase pi (GST pi) were significantly lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines to cisplatin and carboplatin were much higher than those of the 3 NSCLC cell lines. These results indicate that low levels of GST pi mRNA expression in SCLC cell lines inversely correlate to high sensitivity to cisplatin and carboplatin, and further suggest that GST pi may play an important role in intracellular inactivation of these drugs.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Carboplatin
-
Carcinoma, Small Cell / drug therapy
-
Carcinoma, Small Cell / enzymology*
-
Carcinoma, Small Cell / metabolism
-
Cell Line
-
Cisplatin / pharmacology*
-
Drug Resistance
-
Glutathione Transferase / metabolism*
-
Humans
-
Lung Neoplasms / drug therapy
-
Lung Neoplasms / enzymology*
-
Lung Neoplasms / metabolism
-
Organoplatinum Compounds / pharmacology*
-
RNA, Messenger / metabolism*
-
RNA, Neoplasm / metabolism
Substances
-
Organoplatinum Compounds
-
RNA, Messenger
-
RNA, Neoplasm
-
Carboplatin
-
Glutathione Transferase
-
Cisplatin