Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue

Curr Diab Rep. 2017 May;17(5):30. doi: 10.1007/s11892-017-0854-7.


Purpose of review: Precision medicine approaches, that tailor medications to specific individuals has made paradigm-shifting improvements for patients with certain cancer types.

Recent findings: Such approaches, however, have not been implemented for patients with diabetic kidney disease. Precision medicine could offer new avenues for novel diagnostic, prognostic and targeted therapeutics development. Genetic studies associated with multiscalar omics datasets from tissue and cell types of interest of well-characterized cohorts are needed to change the current paradigm. In this review, we will discuss precision medicine approaches that the nephrology community can take to analyze tissue samples to develop new therapeutics for patients with diabetic kidney disease.

Keywords: Diabetic kidney disease; Epigenetics; GWAS; Genetic; Genomics; Kidney biopsy; Precision medicine; eQTL.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Diabetic Nephropathies / drug therapy*
  • Humans
  • Precision Medicine*
  • Prognosis


  • Biomarkers