Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study

Maturitas. 2017 May;99:105-108. doi: 10.1016/j.maturitas.2017.02.015. Epub 2017 Feb 28.


We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characteristics. Two radiologists assessed MD in their left craneo-caudal mammogram, assisted by a validated semiautomatic-computer tool (DM-scan). We used log-transformed percentage MD as the dependent variable and fitted mixed linear regression models, including known confounding variables. Our results showed that neither sleeping patterns nor sleep disorders were associated with MD. However, women with frequent changes in their bedtime due to anxiety or depression had higher MD (eβ:1.53;95%CI:1.04-2.26).

Keywords: Breast cancer; Mammographic density; Sleep disorders; Sleep patterns.

MeSH terms

  • Aged
  • Breast / diagnostic imaging*
  • Breast Density*
  • Breast Neoplasms / epidemiology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Mammography
  • Middle Aged
  • Risk Factors
  • Sleep Wake Disorders / epidemiology*
  • Spain / epidemiology