Preconception gynecological risk factors of postpartum depression among Japanese women: The Japan Environment and Children's Study (JECS)

J Affect Disord. 2017 Aug 1;217:34-41. doi: 10.1016/j.jad.2017.03.049. Epub 2017 Mar 30.


Background: Postpartum depression is one of the major causes of disability among women who are on their childbearing years. Identifying people at risk of postpartum depression may improve its management. The objective of this study was to determine the probable association between postpartum depression and some preconception gynecological morbidities.

Methods: Data from a nationwide birth cohort study, the Japan Environment and Children's study (JECS), up to one month of postpartum were analyzed. To assess postpartum depression, the Edinburgh Postnatal Depression Scale (EPDS) was used; 11 preconception gynecological morbidities were considered as risk factors. Covariates included psychiatric illness history, psychosocial factors, some pregnancy adverse outcomes, birth outcomes, socio-demographic and health behavioral factors.

Results: Except for the prevalence of previous miscarriage, leiomyoma and polycystic ovarian syndrome, depressive women had more gynecological morbidities compared to non-depressive ones. In logistic regression model, endometriosis (OR, 1.27; 95%CI: 1.15-1.41), dysmenorrhea (OR, 1.13; 95%CI: 1.06-1.21) and abnormal uterine bleeding (OR, 1.21; 95%CI: 1.15-1.29) were associated with postpartum depression.

Limitations: CONCLUSION: Women with endometriosis and menstrual problems were at risk of developing postpartum depression. This study suggests a perinatal mental health screening for predisposed women.

Keywords: Gynecological morbidities; Postpartum depression; The JECS.

MeSH terms

  • Cohort Studies
  • Comorbidity
  • Depression, Postpartum / epidemiology*
  • Female
  • Genital Diseases, Female / epidemiology*
  • Humans
  • Japan / epidemiology
  • Pregnancy
  • Prevalence
  • Risk Factors