Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 50 (6), 299-307

Emerging Role of Mitophagy in Human Diseases and Physiology

Affiliations
Review

Emerging Role of Mitophagy in Human Diseases and Physiology

Jee-Hyun Um et al. BMB Rep.

Abstract

Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology. [BMB Reports 2017; 50(6): 299-307].

Conflict of interest statement

CONFLICTS OF INTEREST

The authors have no conflicting financial interests.

Figures

Fig. 1
Fig. 1
The role of mitophagy in normal physiology and human disease. Mitophagy plays an important role in maintaining mitochondria homeostasis and various aspects of cellular function. These roles are critical to prevent developing human diseases and aging-related dysfunctions.

Similar articles

See all similar articles

Cited by 14 PubMed Central articles

See all "Cited by" articles

References

    1. Taylor RW, Turnbull DM. Mitochondrial DNA mutations in human disease. Nat Rev Genet. 2005;6:389–402. doi: 10.1038/nrg1606. - DOI - PMC - PubMed
    1. Kang D, Hamasaki N. Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer. Curr Med Chem. 2005;12:429–441. doi: 10.2174/0929867053363081. - DOI - PubMed
    1. Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Mol Cell. 2016;61:654–666. doi: 10.1016/j.molcel.2016.01.028. - DOI - PMC - PubMed
    1. Baker MJ, Palmer CS, Stojanovski D. Mitochondrial protein quality control in health and disease. Br J Pharmacol. 2014;171:1870–1889. doi: 10.1111/bph.12430. - DOI - PMC - PubMed
    1. Burte F, Carelli V, Chinnery PF, Yu-Wai-Man P. Disturbed mitochondrial dynamics and neurodegenerative disorders. Nat Rev Neurol. 2015;11:11–24. doi: 10.1038/nrneurol.2014.228. - DOI - PubMed

MeSH terms

Feedback