Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study

Reprod Biomed Online. 2017 Jun;34(6):605-610. doi: 10.1016/j.rbmo.2017.03.003. Epub 2017 Mar 14.


Assisted reproductive technologies are well-established treatments for many types of subfertility representing substantial economic and healthcare implications for patients, healthcare providers and society as a whole. In order to optimize outcomes according to the type of gonadotrophins within an oocyte donor programme, we performed an economic evaluation based on data collected in a multicentre, prospective, randomized study within three private clinics belonging to the IVI Group. Results showed no relevant between-group differences in the clinical variables. According to the economic analysis, ovarian stimulation with corifollitropin alfa increased the overall cost of the treatment as well as the cost per retrieved and effective oocyte, although the differences were not statistically significant. In conclusion, cost savings can be achieved using cheaper gonadotrophins during ovarian stimulation. The cost of corifollitropin alfa compared with recombinant FSH and highly purified human menopausal gonadotrophin should be considered when making treatment decisions.

Keywords: Corifollitropin alfa; Cost savings; Cost-effectiveness; Egg donor programme.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Female
  • Follicle Stimulating Hormone, Human / administration & dosage*
  • Follicle Stimulating Hormone, Human / economics
  • Humans
  • Menotropins / administration & dosage*
  • Menotropins / economics
  • Oocyte Donation*
  • Ovulation Induction / economics
  • Ovulation Induction / methods*
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / economics
  • Young Adult


  • Follicle Stimulating Hormone, Human
  • Recombinant Proteins
  • follicle stimulating hormone, human, with HCG C-terminal peptide
  • follitropin beta
  • Menotropins