Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

doi:10.1016/j.bbr.2017.03.043

. 2017 Jun 1:327:162-166.

doi: 10.1016/j.bbr.2017.03.043. Epub 2017 Mar 31.

Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

M Ranchet¹, J Orlosky², J Morgan³, S Qadir⁴, A E Akinwuntan⁵, H Devos⁶

Affiliations

¹ Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; University of Lyon, F-69000 Lyon, France; French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR), TS2, LESCOT, F-69500 Bron, France. Electronic address: maud.ranchet@ifsttar.fr.
² Cybermedia Center, Toyonaka Educational Research Center 5F, Osaka University, 1-32 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
³ Movement and Cognitive Disorders Center, Department of Neurology, Augusta University, GA, USA.
⁴ Medical College of Georgia, Augusta University, GA, USA.
⁵ Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; Dean's Office, School of Health Professions, The University of Kansas Medical Center, Kansas City, KS, USA.
⁶ Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; Department of Physical Therapy and Rehabilitation Science, School of Health Professions, The University of Kansas Medical Center, Kansas City, KS, USA.

PMID: 28366772
DOI: 10.1016/j.bbr.2017.03.043

Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

M Ranchet et al. Behav Brain Res. 2017.

. 2017 Jun 1:327:162-166.

doi: 10.1016/j.bbr.2017.03.043. Epub 2017 Mar 31.

Authors

M Ranchet¹, J Orlosky², J Morgan³, S Qadir⁴, A E Akinwuntan⁵, H Devos⁶

Affiliations

¹ Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; University of Lyon, F-69000 Lyon, France; French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR), TS2, LESCOT, F-69500 Bron, France. Electronic address: maud.ranchet@ifsttar.fr.
² Cybermedia Center, Toyonaka Educational Research Center 5F, Osaka University, 1-32 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
³ Movement and Cognitive Disorders Center, Department of Neurology, Augusta University, GA, USA.
⁴ Medical College of Georgia, Augusta University, GA, USA.
⁵ Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; Dean's Office, School of Health Professions, The University of Kansas Medical Center, Kansas City, KS, USA.
⁶ Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; Department of Physical Therapy and Rehabilitation Science, School of Health Professions, The University of Kansas Medical Center, Kansas City, KS, USA.

PMID: 28366772
DOI: 10.1016/j.bbr.2017.03.043

Abstract

The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score≥26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score<26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.

Keywords: Antisaccade task; Cognitive workload; Executive function; Parkinson’s disease; Prosaccade task.

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Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

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Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

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