[Autophagy in chronic liver diseases: a friend rather than a foe?]

Med Sci (Paris). 2017 Mar;33(3):252-259. doi: 10.1051/medsci/20173303011. Epub 2017 Apr 3.
[Article in French]

Abstract

Within recycling damaged cell components, autophagy maintains cell homeostasis. Thus, it has been anticipated that autophagy would play an essential role in the pathogenesis of chronic liver diseases. Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most prevalent chronic liver diseases in Western countries, sharing common histopathologic features and a common disease progression. In this review, we discuss the role of autophagy at different stages of NAFLD and ALD as well as in liver regeneration and hepatocarcinogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy / physiology*
  • Chronic Disease
  • Disease Progression
  • Humans
  • Liver Diseases / pathology*
  • Liver Diseases / physiopathology
  • Liver Diseases, Alcoholic / pathology
  • Liver Diseases, Alcoholic / physiopathology
  • Non-alcoholic Fatty Liver Disease / pathology
  • Non-alcoholic Fatty Liver Disease / physiopathology