Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells

Int Immunol. 2017 Apr 1;29(4):149-155. doi: 10.1093/intimm/dxx015.

Abstract

Current studies using knockout mice have revealed that some Cys-Cys-Cys-His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system.

Keywords: RNA-binding protein; inflammatory cytokine; mRNA stability; zinc-finger protein.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Immune System / metabolism*
  • Immunity*
  • Immunomodulation
  • RNA Stability*
  • RNA, Messenger / immunology
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Ribonucleases / metabolism*
  • Transcription Factors / metabolism*
  • Tristetraprolin / metabolism*
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • RC3H1 protein, human
  • RNA, Messenger
  • RNA-Binding Proteins
  • Transcription Factors
  • Tristetraprolin
  • Ubiquitin-Protein Ligases
  • Ribonucleases
  • ZC3H12A protein, human