Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Head Neck. 2017 Jun;39(6):1243-1248. doi: 10.1002/hed.24755. Epub 2017 Apr 3.


Background: Mammary analog secretory carcinoma of the salivary glands (MASCSG ) is a newly introduced malignant tumor of the salivary glands. For decades, it has been confused with acinic cell carcinoma (ACC) of the salivary glands.

Methods: All reported cases of MASCSG were surveyed from 2010 until January 2017. The collected data was compiled and computationally processed to describe the clinical parameters of MASCSG . Its epidemiology was also mapped. Moreover, inaccurate data was highlighted.

Results: Clinically implicating, this article tackles simply the several clinical findings of MASCSG so that our contemporary nosology, at 7 years after description, can be updated. The cytogenetic, histologic, and immunohistochemical details are also defined.

Conclusion: The available data about MASCSG is sufficient enough to diagnose it with no need to investigate the ETV6-NTRK3 translocation. Although high-grade malignancy and distant metastases were rarely reported, a rapt attention should be paid both to the nature of this tumor and to the indicated close follow-up of such cases, especially when necrosis, increased mitotic activity, and other classic caveats are conspicuous. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1243-1248, 2017.

Keywords: mammary analog; salivary gland cancers; secretory carcinoma; systematic review.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Aged
  • Biopsy, Needle
  • Combined Modality Therapy
  • Disease-Free Survival
  • ETS Translocation Variant 6 Protein
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Internationality
  • Male
  • Mammary Analogue Secretory Carcinoma / epidemiology*
  • Mammary Analogue Secretory Carcinoma / genetics*
  • Mammary Analogue Secretory Carcinoma / pathology*
  • Mammary Analogue Secretory Carcinoma / therapy
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins c-ets / genetics
  • Repressor Proteins / genetics
  • Risk Assessment
  • Salivary Gland Neoplasms / epidemiology*
  • Salivary Gland Neoplasms / genetics*
  • Salivary Gland Neoplasms / pathology*
  • Salivary Gland Neoplasms / therapy
  • Survival Analysis
  • Time Factors


  • Proto-Oncogene Proteins c-ets
  • Repressor Proteins