Clinical and electrophysiological studies of human immunodeficiency virus-seropositive men without AIDS

Ann Neurol. 1988 Mar;23(3):295-7. doi: 10.1002/ana.410230313.


Motor weakness and ataxia of lower limbs and abnormalities of somatosensory evoked potentials occur in many patients with the acquired immunodeficiency syndrome (AIDS). We studied 15 human immunodeficiency virus-seropositive subjects without AIDS and found no clinical neurological abnormalities. The mean latency of the brainstem auditory evoked potential (peak V) was increased, suggesting a central defect. Despite normal peripheral nerve conduction along the tibial nerve, the mean latency of the spinal cord potential of the twelfth thoracic vertebra was increased compared with normal, possibly indicating an incipient conduction defect at or near the spinal root ganglion or lumbar spinal cord.

MeSH terms

  • Acquired Immunodeficiency Syndrome / physiopathology*
  • Adult
  • Afferent Pathways / physiopathology
  • Brain Stem / physiopathology
  • Cerebral Cortex / physiopathology
  • Electroencephalography*
  • Evoked Potentials, Auditory
  • Evoked Potentials, Somatosensory
  • Evoked Potentials, Visual
  • HIV Seropositivity*
  • Homosexuality
  • Humans
  • Male
  • Median Nerve / physiopathology
  • Nervous System Diseases / physiopathology*
  • Synaptic Transmission*
  • Tibial Nerve / physiopathology