Modulation of the Na,K-ATPase by Ca and intracellular proteins

Annu Rev Physiol. 1988;50:291-303. doi: 10.1146/


The activity of the Na,K-ATPase can be sensitive to physiological changes in Cai. Intracellular proteins such as calnaktin, calmodulin, and protein kinase C could regulate the pump during transient changes in Cai. The mechanisms by which these proteins interact with the Na,K-ATPase, their distribution in different kinds of cells, and their role in regulating the Na,K-ATPase are not yet determined. Preliminary data indicate that an increase in Cai within the physiological range could be associated with either a stimulation or an inhibition of enzyme activity or a change in the affinity of the Na,K-ATPase for ouabain. The type of response probably depends on the kind of cell, its associated intracellular proteins, and its physiological state. Ca and intracellular proteins could play a key role in the regulation of the Na,K-ATPase by hormones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Calcium / physiology*
  • Calmodulin / physiology*
  • Protein Kinase C / physiology*
  • Sodium-Potassium-Exchanging ATPase / physiology*


  • Calmodulin
  • Protein Kinase C
  • Sodium-Potassium-Exchanging ATPase
  • Calcium