Evidence of autocrine regulation in human hepatoma cell lines

Biochem Biophys Res Commun. 1988 May 31;153(1):39-45. doi: 10.1016/s0006-291x(88)81186-0.


Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular / physiopathology*
  • Cell Line
  • Homeostasis
  • Humans
  • Insulin-Like Growth Factor I / genetics
  • Liver Neoplasms / physiopathology*
  • Platelet-Derived Growth Factor / genetics
  • RNA, Messenger / metabolism
  • Receptor, Insulin / genetics
  • Receptors, Somatomedin
  • Transcription, Genetic


  • Platelet-Derived Growth Factor
  • RNA, Messenger
  • Receptors, Somatomedin
  • Insulin-Like Growth Factor I
  • Receptor, Insulin