Abstract
Phaclofen (0.5-1 mM) reversibly inhibited the late, bicuculline resistant, K+ dependent IPSP recorded in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurones. At the same concentrations, phaclofen reversibly blocked the K+ dependent, bicuculline insensitive hyperpolarization evoked by GABA and baclofen but had no effect on the GABAA IPSP. These results represent conclusive evidence that GABAB receptors mediate the late K+ dependent IPSP in cortical and subcortical neurones.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Action Potentials / drug effects
-
Animals
-
Baclofen / analogs & derivatives*
-
Baclofen / pharmacology
-
Bicuculline / pharmacology
-
Cats
-
Electric Stimulation
-
Geniculate Bodies / drug effects
-
Geniculate Bodies / metabolism
-
Geniculate Bodies / physiology*
-
Hippocampus / drug effects
-
Hippocampus / metabolism
-
Hippocampus / physiology*
-
In Vitro Techniques
-
Male
-
Potassium / pharmacology*
-
Rats
-
Rats, Inbred Strains
-
Receptors, GABA-A / drug effects
-
Receptors, GABA-A / physiology*
Substances
-
Receptors, GABA-A
-
phaclofen
-
Baclofen
-
Potassium
-
Bicuculline