The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones

Brain Res. 1988 May 17;448(2):351-4. doi: 10.1016/0006-8993(88)91275-9.

Abstract

Phaclofen (0.5-1 mM) reversibly inhibited the late, bicuculline resistant, K+ dependent IPSP recorded in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurones. At the same concentrations, phaclofen reversibly blocked the K+ dependent, bicuculline insensitive hyperpolarization evoked by GABA and baclofen but had no effect on the GABAA IPSP. These results represent conclusive evidence that GABAB receptors mediate the late K+ dependent IPSP in cortical and subcortical neurones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Baclofen / analogs & derivatives*
  • Baclofen / pharmacology
  • Bicuculline / pharmacology
  • Cats
  • Electric Stimulation
  • Geniculate Bodies / drug effects
  • Geniculate Bodies / metabolism
  • Geniculate Bodies / physiology*
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Male
  • Potassium / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / physiology*

Substances

  • Receptors, GABA-A
  • phaclofen
  • Baclofen
  • Potassium
  • Bicuculline