Family History in Patients with Bipolar Disorder

Noro Psikiyatr Ars. 2016 Sep;53(3):276-279. doi: 10.5152/npa.2015.9870. Epub 2016 Sep 1.


Introduction: In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients.

Methods: Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital.

Results: Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases.

Conclusion: The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.

Keywords: Bipolar disorder; family history; genetic transmission.