Assessing Initial Response to High-Frequency Jet Ventilation in Premature Infants With Hypercapnic Respiratory Failure

Respir Care. 2017 Jul;62(7):867-872. doi: 10.4187/respcare.05264. Epub 2017 Apr 4.


Background: High-frequency jet ventilation (HFJV) has been used in conjunction with conventional ventilation for infants with respiratory failure. We sought to identify parameters that were associated with successful application of HFJV in patients with hypercapnic respiratory failure.

Methods: A single-center, retrospective review of infants who received HFJV was conducted. Subjects were enrolled if birthweight was ≤2,000 g and capillary PCO2 was ≥55 mm Hg. Ventilator parameters and physiologic data were recorded at 1 h before HFJV initiation and at hours 1, 4, and 6 following conversion. Subjects were classified as responders if capillary PCO2 was reduced by ≥10% after 1 h of HFJV. Data included peak inspiratory pressure, PEEP, capillary PCO2 , and oxygen saturation index (equal to mean airway pressure × FIO2 × 100/SpO2 ). Because the data were not normally distributed, they are reported as median (interquartile range), and the Mann-Whitney test was used to assess differences in continuous data between groups. Categorical data were analyzed using a chi-square and Fisher exact test.

Results: Thirty-four premature infants (n = 24 male) were studied. Twenty-five subjects were classified as responders and demonstrated a significant reduction of capillary PCO2 and FIO2 and increased pH within the first hour. The non-responders demonstrated a higher conventional ventilation peak inspiratory pressure (25 cm H2O vs 19 cm H2O, P = .005) and had a greater postmenstrual age (30 weeks vs 26.5 weeks, P = .01). This group had a higher oxygen saturation index (7.25 vs 3.36, P = .03) and FIO2 requirements (0.6 vs 0.35, P = .038) at 4 h.

Conclusions: We identified that lower postmenstrual age, improvements in capillary PCO2 and pH at 1 h, and a reduction of FIO2 were associated with good response to HFJV. These data may help to identify patients who are likely to benefit from HFJV in the neonatal intensive care unit.

Keywords: chronic lung disease; high-frequency jet ventilation; high-frequency oscillatory ventilation; mechanical ventilation; prematurity; respiratory distress syndrome.

Publication types

  • Evaluation Study

MeSH terms

  • Carbon Dioxide / analysis
  • Female
  • Gestational Age
  • High-Frequency Jet Ventilation / methods*
  • Humans
  • Hydrogen-Ion Concentration
  • Hypercapnia / etiology
  • Hypercapnia / physiopathology
  • Hypercapnia / therapy*
  • Infant, Newborn
  • Infant, Premature*
  • Intensive Care Units, Neonatal
  • Male
  • Oxygen Consumption / physiology
  • Pulmonary Ventilation / physiology
  • Respiration, Artificial / methods*
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / physiopathology
  • Respiratory Insufficiency / therapy*
  • Retrospective Studies
  • Treatment Outcome


  • Carbon Dioxide