Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 33 (1), 16-21

Initial Clinical Experience With the Endologix AFX Unibody Stent Graft System for Treating Patients With Abdominal Aortic Aneurysms: A Case Controlled Comparative Study


Initial Clinical Experience With the Endologix AFX Unibody Stent Graft System for Treating Patients With Abdominal Aortic Aneurysms: A Case Controlled Comparative Study

George N Kouvelos et al. Vasc Specialist Int.


Purpose: The newly designed unibody AFX endograft system for endovascular aortic aneurysm repair is the only graft with anatomical fixation to the aortic bifurcation in comparison to most other grafts that use the infrarenal neck as the main fixation point. The aim of this study was to assess the preliminary results of the AFX stent-graft system used with infrarenal aortic component and compare them with those obtained in patients treated with a well established endograft of the same material and pure infrarenal fixation as the Gore Excluder.

Materials and methods: A retrospective analysis of prospectively collected data from March 2014 to December 2014 identified 10 elective abdominal aortic aneurysm patients treated with the AFX endograft, in comparison to a matched group of 20 patients treated with the Excluder stent-graft. Endpoints included technical and clinical success, freedom from any secondary intervention, any type of endoleak and aneurysm related death.

Results: Primary technical success was achieved in all patients and no 30-day device related complications or deaths were occurred. The two groups were similar in terms of radiation burden, contrast media, duration of the procedure, post implantation syndrome and in-hospital stay. During a median follow-up period of 23 months (range, 18-26 months) there were no differences in clinical success, freedom from reintervention and aneurysm related death. No type I endoleak was observed in either group. Five of the 6 type II endoleaks (1 in the AFX and 4 in the Excluder group) spontaneously resolved, while in only one patient (Excluder) the endoleak remained without however any change in aneurysm sac diameter (log rank=0.34).

Conclusion: The initial experience with the AFX stent graft system is promising, with successful aneurysm exclusion and good short-term results. Further and larger studies are needed to fully evaluate the sort as well as the long-term results.

Keywords: AFX graft; Aneurysm; Endovascular; Endovascular aortic aneurysm repair.


Fig. 1
Fig. 1
(A) Preoperative three-dimensional volume-rendered computed tomography reconstruction of an abdominal aortic aneurysm 6.2 cm in diameter. (B) Computed tomography angiography reconstruction 2 years after the procedure.

Similar articles

See all similar articles

Cited by 1 PubMed Central articles


    1. Park BD, Azefor NM, Huang CC, Ricotta JJ. Elective endovascular aneurysm repair in the elderly: trends and outcomes from the nationwide inpatient sample. Ann Vasc Surg. 2014;28:798–807. doi: 10.1016/j.avsg.2013.07.029. - DOI - PubMed
    1. United Kingdom EVAR Trial Investigators. Greenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D, et al. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med. 2010;362:1863–1871. doi: 10.1056/NEJMoa0909305. - DOI - PubMed
    1. Buckley CJ, Buckley SD. Deficiencies with current aortic endografts. J Cardiovasc Surg (Torino) 2015;56:369–373. - PubMed
    1. Diethrich EB. Novel sealing concept in the Endologix AFX unibody stent-graft. J Cardiovasc Surg (Torino) 2014;55:93–102. - PubMed
    1. Melas N, Stavridis K, Saratzis A, Lazarides J, Gitas C, Saratzis N. Active proximal sealing in the endovascular repair of abdominal aortic aneurysms: early results with a new stent-graft. J Endovasc Ther. 2015;22:174–178. doi: 10.1177/1526602815573232. - DOI - PubMed

LinkOut - more resources