Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval

Sci Rep. 2017 Apr 5:7:46024. doi: 10.1038/srep46024.


Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggrecans / metabolism
  • Amygdala / metabolism
  • Animals
  • Cell Aggregation
  • Fear
  • Male
  • Memory*
  • Mental Recall*
  • Mice, Inbred C57BL
  • Nerve Net / physiology*
  • Neurons / metabolism*
  • Parvalbumins / metabolism
  • Proto-Oncogene Proteins c-fos / metabolism


  • Aggrecans
  • Parvalbumins
  • Proto-Oncogene Proteins c-fos