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. 2017 Aug 1;33(15):2413-2415.
doi: 10.1093/bioinformatics/btx162.

SynergyFinder: a web application for analyzing drug combination dose-response matrix data

Aleksandr Ianevski  1 , Liye He  1 , Tero Aittokallio  1   2 , Jing Tang  1   2
Affiliations

SynergyFinder: a web application for analyzing drug combination dose-response matrix data

Aleksandr Ianevski et al. Bioinformatics. .

Erratum in

Abstract

Summary: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner.

Availability and implementation: The SynergyFinder web application is freely accessible at https://synergyfinder.fimm.fi ; The R-package and its source-code are freely available at http://bioconductor.org/packages/release/bioc/html/synergyfinder.html .

Contact: jing.tang@helsinki.fi.

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Figures

Fig. 1
Fig. 1
The outcome panels of the SynergyFinder web application. (a) Visualization of the dose–response matrix and the plots of phenotypic responses for the single drugs. (b) Visualization of the calculated 2D and 3D synergy maps
See this image and copyright information in PMC

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