SynergyFinder: a web application for analyzing drug combination dose-response matrix data

Bioinformatics. 2017 Aug 1;33(15):2413-2415. doi: 10.1093/bioinformatics/btx162.


Summary: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner.

Availability and implementation: The SynergyFinder web application is freely accessible at ; The R-package and its source-code are freely available at .


MeSH terms

  • Computational Biology / methods*
  • Drug Combinations
  • Drug Synergism*
  • Humans
  • Models, Biological*
  • Software*


  • Drug Combinations