SCUBE1: a promising biomarker in renal cell cancer

Int Braz J Urol. 2017 Jul-Aug;43(4):638-643. doi: 10.1590/S1677-5538.IBJU.2016.0316.


Purpose: To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) as a novel biomarker of renal tumors.

Materials and methods: 48 individuals were included in the study. The patient group (Group-1) consisted of 23 subjects diagnosed with renal tumor, and the control group (Group-2) of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected following overnight fasting. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1), soluble urokinase plasminogen activator receptor (suPAR) and carbonic anhydrase IX (CA IX) levels were measured from plasma samples. Patients in groups 1 and 2 were compared in terms of these biochemical parameters.

Results: The 23-member renal tumor group was made up of 17 (73.91%) male and 6 (26.08%) female patients with a mean age of 58.5±15.7 years (range 25 to 80). The 24-member healthy control group was made up of 16 (64%) male and 9 (36%) female subjects with a mean age of 52.4±9.12 years (range 40 to 67). Analysis revealed significant elevation in SCUBE-1 levels in the renal tumor group (p=0.005). No significant differences were detected between the groups with regard to CA IX or suPAR measurements (p=0.062 vs. p=0.176).

Conclusions: SCUBE-1 appears to represent a promising biomarker in the diagnosis and follow-up of patients with renal tumor.

Keywords: Biomarkers; Carcinoma, Renal Cell.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood
  • Calcium-Binding Proteins
  • Carbonic Anhydrase IX / blood*
  • Carcinoma, Renal Cell / blood*
  • Carcinoma, Renal Cell / diagnosis
  • Case-Control Studies
  • Female
  • Humans
  • Kidney Neoplasms / blood*
  • Kidney Neoplasms / diagnosis
  • Male
  • Membrane Proteins / blood*
  • Middle Aged
  • Receptors, Urokinase Plasminogen Activator / blood*


  • Biomarkers, Tumor
  • Calcium-Binding Proteins
  • Membrane Proteins
  • Receptors, Urokinase Plasminogen Activator
  • SCUBE1 protein, human
  • Carbonic Anhydrase IX