Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study

J Cosmet Dermatol. 2017 Jun;16(2):258-264. doi: 10.1111/jocd.12341. Epub 2017 Apr 5.


Background: The escalating urge for a youthful-looking skin instigates continuous innovations with minimally invasive procedures. Readymade growth factors and autologous platelet-rich plasma (PRP) represent such therapeutic interventions.

Objective: Compare the efficacy and safety of PRP to readymade growth factors in skin rejuvenation.

Patients and methods: Twenty adult females with Fitzpatrick skin types III-IV and Glogau photoaging types II and III were enrolled in this study. They underwent a split face therapy where each side was randomly assigned to treatment by either readymade growth factors (area A) or autologous PRP (area B). All patients received six sessions at 2-weeks interval. Evaluation was carried out using Global Aesthetic Improvement Scale (GAIS) and optical coherence tomography (OCT). Patients were followed up for 6 months.

Results: Both procedures yielded significant improvement regarding both GAIS (skin turgor and overall vitality) and OCT (epidermal and dermal thickness) assessment. Significant negative correlation was detected between patients' age, sun exposure, and GAIS. Burning sensation was significantly higher in area A. Patient satisfaction was significantly higher in area B. Improvement was more sustained in area B on follow-up.

Conclusion: Platelet-rich plasma is effective and safe for skin rejuvenation, comparable to readymade growth factors with noticeable higher longevity.

Keywords: OCT; PRP; efficacy; readymade growth factors; skin rejuvenation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cosmetic Techniques*
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins*
  • Middle Aged
  • Platelet-Rich Plasma*
  • Prospective Studies
  • Rejuvenation*
  • Skin*


  • Intercellular Signaling Peptides and Proteins