Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein

Ovchinnikov YuA; G S Monastyrskaya; N E Broude; Ushkaryov YuA; A M Melkov; Smirnov YuV; I V Malyshev; R L Allikmets; M B Kostina; I E Dulubova

doi:10.1016/0014-5793(88)81361-9

Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein

FEBS Lett. 1988 Jun 6;233(1):87-94. doi: 10.1016/0014-5793(88)81361-9.

Authors

Ovchinnikov YuA¹, G S Monastyrskaya, N E Broude, Ushkaryov YuA, A M Melkov, Smirnov YuV, I V Malyshev, R L Allikmets, M B Kostina, I E Dulubova, et al.

Affiliation

¹ Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.

PMID: 2838329
DOI: 10.1016/0014-5793(88)81361-9

Abstract

The primary structure of a gene of the Na+, K+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical alpha III-form of the enzyme catalytic subunit. The gene comprises over 25,000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Animals
Bacteriophage lambda / genetics
Base Composition
Base Sequence
Binding Sites
Catalysis
DNA / genetics
DNA, Recombinant
Exons
Humans
Introns
Molecular Sequence Data
Sodium-Potassium-Exchanging ATPase / genetics*

Substances

DNA, Recombinant
DNA
Sodium-Potassium-Exchanging ATPase