Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle

J Vet Sci. 2017 Dec 31;18(4):555-558. doi: 10.4142/jvs.2017.18.4.555.

Abstract

A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.

Keywords: adipose-derived mesenchymal stromal cells; bone morphogenetic protein 7; dogs; ununited fractures.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 7 / therapeutic use*
  • Dogs / injuries*
  • Dogs / surgery
  • Fractures, Ununited / surgery
  • Fractures, Ununited / therapy
  • Fractures, Ununited / veterinary*
  • Male
  • Mesenchymal Stem Cell Transplantation / veterinary*

Substances

  • Bone Morphogenetic Protein 7