Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia

Med Mycol Case Rep. 2017 Mar 23:16:8-11. doi: 10.1016/j.mmcr.2017.03.003. eCollection 2017 Jun.


Central Nervous System (CNS) vasculitis is the most common life-threatening complication of coccidioidal meningitis. It is manifested by cerebral ischemia, hemorrhage, and infarction. We report a case of CNS vasculitis in a patient receiving chemotherapy and review of the literature on coccidioidal meningitis. The patient was treated with combination antifungal therapy and a short course of high dose corticosteroids with a modest improvement in her neurological examination after initiation of steroids.

Keywords: Cerebral vasculitis; Coccidioidal meningitis; Disseminated coccidioidomycosis; Fungal meningitis; Steroid.