Medulloblastoma: Molecular Classification-Based Personal Therapeutics

Neurotherapeutics. 2017 Apr;14(2):265-273. doi: 10.1007/s13311-017-0526-y.


Recent advances in cancer genomics have revealed 4 distinct subgroups of medulloblastomas, each with unique transcription profiles, DNA alterations and clinical outcome. Molecular classification of medulloblastomas improves predictions of clinical outcome, allowing more accurate matching of intensity of conventional treatments with chemotherapy and radiation to overall prognosis and setting the stage for the introduction of targeted therapies.

Keywords: DNA methylation; Genomic; Group 3; Group 4; MYC; Medulloblastoma; SHH; Subgroups; WHO; WNT.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cerebellar Neoplasms / classification*
  • Cerebellar Neoplasms / genetics*
  • Cerebellar Neoplasms / metabolism
  • Genomics
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma / classification*
  • Medulloblastoma / genetics*
  • Medulloblastoma / metabolism
  • Mutation
  • Precision Medicine*
  • Signal Transduction*
  • Wnt Signaling Pathway


  • Hedgehog Proteins
  • SHH protein, human