Drosophilosophical: Re-thinking Adaptive Immunity in the Fly

Cara West; Neal Silverman

doi:10.1016/j.cell.2017.03.032

Drosophilosophical: Re-thinking Adaptive Immunity in the Fly

Cell. 2017 Apr 6;169(2):188-190. doi: 10.1016/j.cell.2017.03.032.

Authors

Cara West¹, Neal Silverman²

Affiliations

¹ Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: neal.silverman@umassmed.edu.

PMID: 28388404
DOI: 10.1016/j.cell.2017.03.032

Abstract

For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes.

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MeSH terms

Adaptive Immunity*
Animals
Humans
Immunity, Innate / genetics
RNA Interference*