An Unchartered Journey for Ribosomes: Circumnavigating Circular RNAs to Produce Proteins

Mol Cell. 2017 Apr 6;66(1):1-2. doi: 10.1016/j.molcel.2017.03.011.


In this issue of Molecular Cell, Legnini et al. (2017) and Pamudurti et al. (2017) demonstrate that endogenous circular RNAs may generate proteins, thereby expanding the eukaryotic proteome and revealing novel modes of cap-independent translation.

Keywords: IRES; backsplicing; cap-independent translation; circRNA; eIF3; m6A; polysome; pre-mRNA splicing; ribosome profiling; stress.

MeSH terms

  • Humans
  • Protein Biosynthesis
  • Proteins*
  • RNA, Messenger
  • Ribosomes*


  • Proteins
  • RNA, Messenger