An Unchartered Journey for Ribosomes: Circumnavigating Circular RNAs to Produce Proteins

Deirdre C Tatomer; Jeremy E Wilusz

doi:10.1016/j.molcel.2017.03.011

An Unchartered Journey for Ribosomes: Circumnavigating Circular RNAs to Produce Proteins

Mol Cell. 2017 Apr 6;66(1):1-2. doi: 10.1016/j.molcel.2017.03.011.

Authors

Deirdre C Tatomer¹, Jeremy E Wilusz²

Affiliations

¹ Department of Biochemistry & Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
² Department of Biochemistry & Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: wilusz@mail.med.upenn.edu.

PMID: 28388436
DOI: 10.1016/j.molcel.2017.03.011

Abstract

In this issue of Molecular Cell, Legnini et al. (2017) and Pamudurti et al. (2017) demonstrate that endogenous circular RNAs may generate proteins, thereby expanding the eukaryotic proteome and revealing novel modes of cap-independent translation.

Keywords: IRES; backsplicing; cap-independent translation; circRNA; eIF3; m6A; polysome; pre-mRNA splicing; ribosome profiling; stress.

MeSH terms

Humans
Protein Biosynthesis
Proteins*
RNA, Messenger
Ribosomes*

Substances

Proteins
RNA, Messenger

Abstract

MeSH terms

Substances

Grant support