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Review
. 2017 Apr 7;292(14):6027-6028.
doi: 10.1074/jbc.H117.777714. Epub 2017 Apr 7.

Exposing HIV's Weaknesses

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Free PMC article
Review

Exposing HIV's Weaknesses

Philip R Tedbury et al. J Biol Chem. .
Free PMC article

Abstract

The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms. Sood and co-workers now show that SERINC5 suppresses HIV-1 fusogenicity and increases sensitivity to neutralizing antibodies by perturbing the folding of the fusion machinery. This work advances our understanding of host-virus interactions and provides a compelling case for considering the host immune system in studies of restriction factor mechanisms.

Conflict of interest statement

The authors declare that they have no conflicts of interest with the contents of this article

Figures

Figure 1.
Figure 1.
Potential inhibitory mechanisms of SERINC5. A, in the absence of SERINC5, binding of the envelope protein to its receptor triggers refolding and membrane fusion. In the presence of SERINC5 and the absence of Nef, SERINC5 (in red) may slow the refolding of envelope, increasing the window of opportunity for neutralizing antibodies to bind (B), or SERINC5 may promote structural changes in envelope (C), rendering it susceptible to neutralization.

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