Exposing HIV's weaknesses

J Biol Chem. 2017 Apr 7;292(14):6027-6028. doi: 10.1074/jbc.H117.777714. Epub 2017 Apr 7.


The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms. Sood and co-workers now show that SERINC5 suppresses HIV-1 fusogenicity and increases sensitivity to neutralizing antibodies by perturbing the folding of the fusion machinery. This work advances our understanding of host-virus interactions and provides a compelling case for considering the host immune system in studies of restriction factor mechanisms.

Publication types

  • Review

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • HIV Antibodies / immunology*
  • HIV Infections / immunology*
  • HIV-1 / immunology*
  • Humans
  • Membrane Proteins / immunology*
  • Protein Folding*
  • Virus Internalization*


  • Antibodies, Neutralizing
  • HIV Antibodies
  • Membrane Proteins
  • SERINC5 protein, human