Imprinting with oxytocin and vasopressin in Chang liver cell cultures: hormonal overlap, binding and influence on cell division

Acta Physiol Hung. 1988;71(1):35-40.


In Chang liver cells the administration of oxytocin and vasopressin as well as the combined application of the two hormones will result in a positive binding imprinting for oxytocin and a negative binding imprinting for vasopressin. The hormones are able to increase the mitotic capacity of the liver cells even without previous imprinting, both in the case of treatment for 4 hours and for 24 hours; the change, however, is more marked in the case of treatment for 4 hours. Treatment for 24 hours results also in some functional imprinting.

MeSH terms

  • Cell Division / drug effects
  • Cell Line
  • Humans
  • Liver / embryology
  • Liver / metabolism*
  • Oxytocin / metabolism*
  • Oxytocin / pharmacology
  • Receptors, Angiotensin / metabolism
  • Receptors, Oxytocin
  • Receptors, Vasopressin
  • Time Factors
  • Vasopressins / metabolism*
  • Vasopressins / pharmacology


  • Receptors, Angiotensin
  • Receptors, Oxytocin
  • Receptors, Vasopressin
  • Vasopressins
  • Oxytocin